Stronger evidence: Ashwagandha (several randomized trials for stress reduction and cortisol lowering), L-theanine (trials for relaxation and cognitive focus), magnesium (for anxiety in deficiency and sleep support).
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Moderate / plausible evidence: Flavonoids (apigenin, luteolin, resveratrol) — good mechanistic and preclinical data; human evidence supportive but patchy for anxiety specifically.
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More speculative in humans: Direct, replicable evidence that a multi-ingredient product reliably increases NPY in humans and that this explains clinical effects — this is an interesting mechanistic hypothesis but needs independent clinical confirmation. Treat the NPY claim as biologically plausible, not yet conclusively demonstrated at the supplement level.
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